[Federal Register Volume 88, Number 153 (Thursday, August 10, 2023)]
[Notices]
[Pages 54319-54320]
From the Federal Register Online via the Government Publishing Office [www.gpo.gov]
[FR Doc No: 2023-17129]
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DEPARTMENT OF HEALTH AND HUMAN SERVICES
Centers for Disease Control and Prevention
[Docket Number CDC-2023-0057, NIOSH-156-F]
Request for Public Comment on the Draft Immediately Dangerous to
Life or Health (IDLH) Value Document for Hydrogen Chloride
AGENCY: Centers for Disease Control and Prevention (CDC), Department of
Health and Human Services (HHS).
ACTION: Request for comment.
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SUMMARY: The National Institute for Occupational Safety and Health
(NIOSH) in the Centers for Disease Control and Prevention (CDC), an
Operating Division of the Department of Health and Human Services
(HHS), requests public comment and technical review on the draft
Immediately Dangerous to Life or Health (IDLH) Value Profile document
for the chemical hydrogen chloride (CAS# 7647-01-0).
DATES: Electronic or written comments must be received by October 10,
2023.
ADDRESSES: You may submit comments, identified by docket number CDC-
2023-0057 and docket number NIOSH-156-F, by either of the following
methods:
[[Page 54320]]
Federal eRulemaking Portal: https://www.regulations.gov.
Follow the instructions for submitting comments.
Mail: National Institute for Occupational Safety and
Health, NIOSH Docket Office, 1090 Tusculum Avenue, MS C-34, Cincinnati,
Ohio 45226-1998.
Instructions: All information received in response to this notice
must include the agency name and docket number (CDC-2023-0057; NIOSH-
156-F). All relevant comments, including any personal information
provided, will be posted without change to https://www.regulations.gov.
Do not submit comments by email. CDC does not accept comments by email.
For access to the docket to read background documents or comments
received, go to https://www.regulations.gov.
FOR FURTHER INFORMATION CONTACT: R. Todd Niemeier, Ph.D., National
Institute for Occupational Safety and Health, MS-C15, 1090 Tusculum
Avenue, Cincinnati, OH 45226. Telephone: (513) 533-8166.
SUPPLEMENTARY INFORMATION: NIOSH is requesting public comment and
technical review on a draft IDLH Value Profile document for the
chemical hydrogen chloride. To facilitate the review of this document,
NIOSH requests comment on the following specific questions for the
draft Profile document:
1. Does this document clearly outline the health hazards associated
with acute (or short-term) exposures to the chemical? If not, what
specific information is missing from the document?
2. Are the rationale and logic behind the derivation of an IDLH
value for a specific chemical clearly explained? If not, what specific
information is needed to clarify the basis of the IDLH value?
3. Are the conclusions supported by the data?
4. Are the tables clear and appropriate?
5. Is the document organized appropriately? If not, what
improvements are needed?
6. Are you aware of any scientific data reported in government
publications, databases, peer-reviewed journals, or other sources that
should be included within this document?
The draft IDLH Value Profile was developed to provide the
scientific rationale behind derivation of IDLH values for the following
chemical:
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Document # Chemical CAS #
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X-XX............................. Hydrogen Chloride... (#7647-01-0)
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The IDLH Value Profile provides a detailed summary of the health
hazards of acute exposures to high airborne concentrations of the
chemical and the rationale for the IDLH value.
Background: In 2013, NIOSH published Current Intelligence Bulletin
(CIB) 66: Derivation of Immediately Dangerous to Life or Health (IDLH)
Values [http://www.cdc.gov/niosh/docs/2014-100/pdfs/2014-100.pdf]
[NIOSH 2013]. The information presented in this CIB represents the
scientific rationale and the current methodology used to derive IDLH
values. Since the establishment of the IDLH values in the 1970s, NIOSH
has continued to review available scientific data to improve the
protocol used to derive acute exposure guidelines, in addition to the
chemical specific IDLH values.
IDLH values are based on health effects considerations determined
through a critical assessment of the toxicology and human health
effects data. This approach ensures that the IDLH values reflect an
airborne concentration of a substance that represents a high-risk
situation that may endanger workers' lives or health.
The primary steps applied in the establishment of an IDLH value
include the following:
1. Critical review of human and animal toxicity data to identify
potentially relevant studies and characterize the various lines of
evidence that can support the derivation of the IDLH value;
2. Determination of a chemical's mode of action or description of
how a chemical exerts its toxic effects;
3. Application of duration adjustments (time scaling) to determine
30-minute-equivalent exposure concentrations and the conduct of other
dosimetry adjustments, as needed;
4. Experimental or other data to establish a point of departure
(POD) such as lethal concentrations (e.g., LC50), lowest observed
adverse effect level (LOAEL), or no observed adverse effect level
(NOAEL);
5. Selection and application of an uncertainty factor (UF) for POD
or critical adverse effect concentration, identified from the available
studies to account for issues associated with interspecies and
intraspecies differences, severity of the observed effects, data
quality, or data insufficiencies; and
6. Development of the final recommendation for the IDLH value from
the various alternative lines of evidence, with use of a weight-of-
evidence approach to all the data.
Reference
NIOSH [2013]. Current intelligence bulletin 66: derivation of
immediately dangerous to life or health (IDLH) values. Cincinnati,
OH: US Department of Health and Human Services, Centers for Disease
Control and Prevention, National Institute for Occupational Safety
and Health, DHHS (NIOSH) Publication 2014-100.
Dated: August 4, 2023.
John J. Howard,
Director, National Institute for Occupational Safety and Health,
Centers for Disease Control and Prevention.
[FR Doc. 2023-17129 Filed 8-9-23; 8:45 am]
BILLING CODE 4163-18-P